DC CFAR Investigator, Dan Wang, MD, PhD has recently been awarded a R01 from the National Institutes of Health entitled,"Accelerated Aging of Microvessels and Perivascular Adipose Tissue in Women with HIV". This project will study the relationship between antiretroviral therapy (ART) and an increased frequency and earlier onset of vascular events in women with HIV. The researchers will incorporate a novel concept from preliminary cellular and clinical studies positing that specific microRNAs provide a biological clock of cellular senescence with which to calibrate rapid microvascular aging in HIV. This will be the first study to explore premature aging in microvessels and its external regulation by PVAT and microRNAs in HIV positive individuals and may identify candidate targets for subsequent clinical trials intervention.