DC CFAR members, Michael Bukrinsky, MD, PhD, and Sergei Nekhai, PhD, along with their colleagues have published an article in Virology entitled, "Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells".
This article discusses a study that demonstrated a novel role for the monomer MCM5 of the MCM complex in the HIV-1 life cycle. An association was shown of MCM5 subunit with HIV-1 Gag polyprotein during the virion assembly and with viral cores in mature viral particles. The results suggest that MCM5 stimulates non-productive reverse transcription and, when overexpressed in HIV virions, inhibits viral replication in the infected cells.
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