Immunology, Virology and Pathogenesis

The DC CFAR supports research in HIV immunology, virology and pathogenesis. Active areas of research include latency, cure and vaccine development, cholesterol metabolism and HIV-1 evolutionary dynamics.

Active NIH Funding

A Novel FMRI Biomarker of Asymptomatic HIV-Associated Neurocognitive Disorders

5R01MH108466-02
Xiong Jiang, PhD
Georgetown University

 

 

AIDS and Cancer Specimen Resource (ACSR)

4UM1CA181255-04
Sylvia Silver, DA
The George Washington University

Innate NKT Cells in HIV Infection

5R37A1052731-16
Douglas F. Nixon, MD, PhD
The George Washington University

Inhibition of HIV-1 in Sickle Cell Disease

5R01HL125005-03
Sergei Nekhai, PhD
Howard University

Elimination of HIV Using HERV Specific T cells

5R01A1076059-08
Douglas F. Nixon, MD, PhD
The George Washington University 

GPR75: A New CCL5 Receptor that Mediates Neuroprotection Against HIV

5R21NS089446-02
Italo Mocchetti, PhD
Georgetown University 

Mechanisms of Pediatric HIV Neurological Impairment

5R03MH107261-02
Mark Burke, PhD
Howard University

Long-term Immunity Against Toxoplasmosis

2R01AI033325-21A1
Imtiaz Khan, PhD
The George Washington University

Engineered CTL with Inducible AB Secretion; A Tripartite Attack on HIV Reservoirs

1R21AI122391-01
Brad Jones, PhD
The George Washington University

Metabolic Complications of HIV Disease Caused by NEF Released from HIV-infected Cells

1R01HL131473-01
Michael Bukrinsky, MD, PhD
The George Washington University

Structural Characterization of the NEF-Calnexin Complex

1R21AI114471-01A1
Michael Bukrinsky, MD, PhD
The George Washington University

BELIEVE: BENCH TO BED ENHANCED LYMPHOCYTE INFUSIONS TO ENGINEER VIRAL ERADICATION

5UM1AI126617-02

Douglas F. Nixon, MD, PhD

The George Washington University

Multivirus-specific T-cells from Naive CB-Derived T Cells

4P01CA148600-06
Catherine Bollard, MD, MBChB
Children's National Medical Center

DEVELOPING PATHOGEN RECOGNITION RECEPTOR AGONISTS AS LATENCY REVERSING AGENTS

 5R01AI124722-03

Alberto Bosque-Pardos, PhD, MBA

The George Washington University

Accelerated Aging of Microvessels and Perivascular Adipose Tissue in Women with HIV

1R01HL134511-01
Dan Wang, MD, PhD
Georgetown University

ASSESSING THE CNS AS A SOURCE OF HIV REBOUND, AND EVALUATING STRATEGIES FOR IMMUNE-MEDIATED RESERVOIR ELIMINATION

The George Washington University

Role of Cytokines and APOL-1 in the Pathogenesis of Childhood HIV Associated NEPH

5R01DK103564-02
Patricio Ray, MD
Children's National Medical Center

CTL-MEDIATED ELIMINATION OF REPLICATION COMPETENT VS. DEFECTIVE HIV PROVIRUSES FROM NATURAL LATENT RESERVOIRS: ROLES OF ANTIGEN

1R01AI131798-01A1
Brad R. Jones, PhD
The George Washington University

Pathogenesis of Chronic Renal Injury and Hypertension in HIV-infected Children

1R01DK108368-01
Patricio Ray, MD
Children's National Medical Center

REPLICATION COST TO HIV-1 AFTER ESCAPE FROM BROADLY NEUTRALIZING ANTIBODIES

5K22AI114299-02 
Rebecca Lynch, PhD
The George Washington University


 

Role of bfgf Low Affinity Receptors in Childhood HIVAN

2R01DK049419-15
Patricio Ray, MD
Children's National Medical Center

HIV INDUCED ANTI-CANCER HERV IMMUNITY IN PROSTATE, BREAST AND COLON CANCERS

5R01CA206488-02
Douglas Nixon, MD, PhD
The George Washington University

GP120 BINDS TO NEURONAL MICROTUBULES: A NEW MECHANISM FOR SYNAPTIC SIMPLIFICATION

1R21NS104000-01
Italo Mocchetti, PhD
Georgetown University

A FAMILY OF COMPOUNDS THAT REACTIVATE LATENT HIV WITHOUT T CELL ACTIVATION

5R33AI116212-05
A
lberto Bosque, PhD, MBA
The George Washington University

CHARACTERIZATION OF COCAINE INDUCED SIGNALING PATHWAYS THAT ENHANCES HIV TRANSCRIPTION

1R01DA041746-01
Mudit Tyagi, PhD
The George Washington University