The Center for Functional and Molecular Imaging (CFMI) provides access to a 3T MRI Scanner, a stand-alone high-density EEG system and two Near Infrared Spectroscopy (NIRS) systems.
Services and Instrumentation
3T MRI Scanner
This instrument can perform functional MRI (fMRI) to examine neuronal activation using different cognitive paradigms; single voxel spectroscopy (SVS) and mutli-voxel spectroscopy to examine concentration of different metabolites in vivo; diffusion tensor imaging (DTI) to examine white matter tract integrity; and voxel-based morphometry (VBM) to examine changes in gray and white matter density.
- 3.0 Tesla Siemens (Erlangen, Germany) Tim Trio whole-body MRI system with EPI (echo planar imaging) capability
- 40mT/m maximum strength gradient system with a slew-rate of 200T/m/sec
- RF-system with 14 parallel receiver channels each with a 1MHz bandwidth
- Console room with a two stimulus presentation systems
The EEG Laboratory is a fully equipped electrophysiology laboratory, which will allow experiments combining the superb temporal resolving capabilities EEG approaches with the sensitivity and spatial resolving properties of functional MRI. The integration of electrophysiology and other imaging modalities will allow investigation of research questions probing modulations in the spatiotemporal character of brain activity.
- Electrical Geodesics high-density EEG system. The EGI GES 250 digitizes 256 channels of data up to 1000 samples/sec, with a 0.1 to 300 Hz bandwidth, and a vertex recording reference
- Advanced software for electrode impedance control and eye movement artifact rejection
- Averaged event-related potentials (ERPs) can be examined with both topographic waveform plots and surface electrical field animations (maps every 4 ms sample) for each experimental condition.
Near Infrared Spectroscopy
Near Infrared Spectroscopy (NIRS) is similar to fMRI and can be used to examine cortical activity based on hemodynamic changes especially in those subjects for whom MRI is not an option.
- Continuous-wave Near Infrared Spectroscopy system with 32 lasers and 32 detectors, which can generate light at different frequencies allowing for the detection of changes in both oxy- and deoxy-hemoglobin
- Customizable system incudes mesh caps of various sizes with sockets into which the optical sensor or optodes can be plugged
The CFMI is directed by Dr. John VanMeter an Assistant Professor in the Department of Neurology at Georgetown University Medical Center. Dr. VanMeter is available to consult with DC CFAR investigators on relevant grant applications.
- Basic Sciences
- Virus Detection and Analysis Molecular Virology
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- Research Pathology
- Flow Cytometry and Cellular Immunology
- Multiparametric Flow Cytometry
- Biacore Molecular Interaction Shared Resource
- Microscopy and Imaging
- Center for Functional and Molecular Imaging
- Basic Sciences Core Virtual Events Recording
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- Request Core Services
- Acknowledge Funding and Services
District of Columbia Center for AIDS Research
Supported by the following Co-Funding and Participating Institutes: NIAID, NCI, NICHD, NIDCR, NHLBI, NIDA, NIMH, NIA, NIDDK, NINR, NIMHD, FIC, and OAR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. (P30AI117970)