The Biacore Molecular Interaction Shared Resource (BMISR) provides customized biomolecular analysis services. This technology involves the immobilization of a ligand on a sensor chip followed by delivery of an analyte by a microfluidic system.
Any protein, DNA, RNA, lipid, carbohydrate, polysaccharide, cell, virus, drug or drug-like molecule (organic or inorganic) can be used as the ligand or analyte.
Services and Instrumentation
The Biacore T-200 and Biacore 4000 instruments in the facility utilizes Surface Plasmon Resonance (SPR) technology to study biomolecular binding events. In addition to identifying binding partners to a target molecule, SPR also provides quantitative data on:
- Specificity: How specific is the binding between two molecules?
- Concentration: How much of a given molecule is present and active?
- Kinetics: What is the rate of association and dissociation?
- Affinity: How strong is the binding?
- Thermodynamics: What is the enthalpy and entropy of the interaction?
- Screening: Which chemical compounds are potential binders?
Dr. Aykut Üren is the Director of the BMISR at Georgetown University where he is also a Professor of Oncology. Dr. Üren and laboratory staff are available to consult with DC CFAR investigators on the design and development of relevant grant applications.
- Basic Sciences
- Virus Detection and Analysis Molecular Virology
- Next Generation Sequencing
- RCMI Proteomics
- Artificial Intelligence and Drug Discovery
- Research Pathology
- Flow Cytometry and Cellular Immunology
- Multiparametric Flow Cytometry
- Biacore Molecular Interaction Shared Resource
- Microscopy and Imaging
- Center for Functional and Molecular Imaging
- Basic Sciences Core Virtual Events Recording
- Clinical and Population Sciences
- Social and Behavioral Sciences
- Request Core Services
- Acknowledge Funding and Services
District of Columbia Center for AIDS Research
Supported by the following Co-Funding and Participating Institutes: NIAID, NCI, NICHD, NIDCR, NHLBI, NIDA, NIMH, NIA, NIDDK, NINR, NIMHD, FIC, and OAR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. (P30AI117970)