New Publication from DC CFAR Microgrant Awardee, Robert Furler, PhD

Dr. Robert Furler Photo
July 23, 2018
DC CFAR microgrant awardee, Robert Furler, PhD, along with his colleagues, has published an article in Cancers entitled, "TGF-beta Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction".
This article discusses the results from a study looking at transforming growth factor β (TGF-β) signaling and its role in promoting tumor growth. TGF-β) signaling can dampen immune responses during cancer progression through biochemical and mechanical signal transduction pathways. Because TGF-β receptors (TGF-βR's) are found on several cell types, tumor-derived TGF-β can create a pro-tumorigenic microenvironment by influencing the activity of surrounding leukocytes, endothelial cells, and fibroblasts. The researchers reviewed the role ofTGF-β activated kinase 1 (TAK1) activation at the intersection of proinflammatory signaling by immune receptors and anti-inflammatory signaling by TGF-β receptors. Additionally, they examined the role of TGF-β in the mechanobiology of cancer. They concluded that understanding how TGF-β dampens proinflammatory responses and induces pro-survival mechanical signals throughout cancer development is critical for designing therapeutics that inhibit tumor progression while bolstering the immune response.
Click here to read the full article.